Affiliation:
1. Section on Molecular Virology, National Institute of Mental Health, NIH, Bethesda, Maryland
Abstract
ABSTRACT
Recently, a new endogenous koala gammaretrovirus, designated KoRV, was isolated from koalas. The KoRV genome shares 78% nucleotide identity with another gammaretrovirus, gibbon ape leukemia virus (GALV). KoRV is endogenous in koalas, while GALV is exogenous, suggesting that KoRV predates GALV and that gibbons and koalas acquired the virus at different times from a common source. We have determined that subtle adaptive differences between the KoRV and GALV envelope genes account for differences in their receptor utilization properties. KoRV represents a unique example of a gammaretrovirus whose envelope has evolved to allow for its expanded host range and zoonotic potential.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference15 articles.
1. Albritton, L. M., L. Tseng, D. Scadden, and J. M. Cunningham. 1989. A putative murine ecotropic receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection. Cell57:659-666.
2. Bromham, L. D. 2002. The human zoo: endogenous retroviruses in the human genome. Trends Ecol. Evol.17:91-97.
3. Fusion-Defective Gibbon Ape Leukemia Virus Vectors Can Be Rescued by Homologous but Not Heterologous Soluble Envelope Proteins
4. Gifford, R., and M. Tristem. 2003. The evolution, distribution and diversity of endogenous retroviruses. Virus Genes26:291-315.
5. Hanger, J., J. McKee, R. Tarlinton, and A. Yates. 2003. Cancer and haematological disease in koalas: a clinical and virological update, p. 19-37. Proceedings of the Annual Conference of the Australian Association of Veterinary Conservation Biologists. CSIRO Publishing, Cairns, Australia.
Cited by
49 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献