ZitB (YbgR), a Member of the Cation Diffusion Facilitator Family, Is an Additional Zinc Transporter in Escherichia coli

Author:

Grass Gregor1,Fan Bin2,Rosen Barry P.2,Franke Sylvia3,Nies Dietrich H.3,Rensing Christopher1

Affiliation:

1. Department of Soil, Water, and Environmental Science, University of Arizona, Tucson, Arizona 857211;

2. Department of Biochemistry and Molecular Biology, Wayne State University, Detroit, Michigan 482012; and

3. Institut für Mikrobiologie, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle, Germany3

Abstract

ABSTRACT The Escherichia coli zitB gene encodes a Zn(II) transporter belonging to the cation diffusion facilitator family. ZitB is specifically induced by zinc. ZitB expression on a plasmid rendered zntA -disrupted E. coli cells more resistant to zinc, and the cells exhibited reduced accumulation of 65 Zn, suggesting ZitB-mediated efflux of zinc.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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