Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice-Reference-Cited by-同舟云学术

Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice

Published:2023-02-16 Issue:2 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Wilburn Kaley M.¹^ORCID,Meade Rachel K.¹²^ORCID,Heckenberg Emma M.¹^ORCID,Dockterman Jacob³,Coers Jörn¹²³^ORCID,Sassetti Christopher M.⁴,Olive Andrew J.⁵^ORCID,Smith Clare M.¹²⁶^ORCID

Affiliation:

1. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA

2. University Program in Genetics and Genomics, Duke University, Durham, North Carolina, USA

3. Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA

4. Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

5. Department of Microbiology and Molecular Genetics, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA

6. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA

Abstract

Mycobacterium tuberculosis ( Mtb ) is a bacterium that exclusively resides in human hosts and remains a dominant cause of morbidity and mortality among infectious diseases worldwide. Host protection against Mtb infection is dependent on the function of immunity-related GTPase clade M (IRGM) proteins.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00510-22

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