Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria-Reference-Cited by-同舟云学术

Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

Published:2006-09-08 Issue:5792 Volume:313 Page:1438-1441
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Singh Sudha B.¹²³⁴,Davis Alexander S.¹²³⁴,Taylor Gregory A.¹²³⁴,Deretic Vojo¹²³⁴

Affiliation:

1. Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.

2. Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.

3. Department of Medicine, Department of Molecular Genetics and Microbiology, Department of Immunology, Center for the Study of Aging, Duke University, Durham, NC 27710, USA.

4. Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Medical Center, Durham, NC 27710, USA.

Abstract

Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis . We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. p47 GTPases: regulators of immunity to intracellular pathogens

2. Immune control of phagosomal bacteria by p47 GTPases

3. Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

4. Disruption of Toxoplasma gondii Parasitophorous Vacuoles by the Mouse p47-Resistance GTPases

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