Affiliation:
1. School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720
Abstract
ABSTRACT
Resistance to reactive oxygen intermediates and reactive nitrogen intermediates in vitro of a clinical isolate of
Mycobacterium tuberculosis
(CDC1551) that caused a large outbreak of tuberculosis was compared to that of
M. tuberculosis
strains CB3.3, H37Rv, H37Ra, Erdman, RJ2E, C.C. 13, and C.C. 22 as well as
M. bovis
strains Ravenel and BCG. CDC1551 and CB3.3 were significantly more resistant to both hydrogen peroxide (H
2
O
2
) and acidified sodium nitrite than were the other strains tested. This biological phenotype may serve as an in vitro marker for clinical strains of
M. tuberculosis
likely to cause a large outbreak of tuberculosis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
26 articles.
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