A Fluorinated Phenylbenzothiazole Arrests the Trypanosoma cruzi Cell Cycle and Diminishes the Infection of Mammalian Host Cells-Reference-Cited by-同舟云学术

A Fluorinated Phenylbenzothiazole Arrests the Trypanosoma cruzi Cell Cycle and Diminishes the Infection of Mammalian Host Cells

Published:2020-01-27 Issue:2 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cuevas-Hernández Roberto I.¹²,Girard Richard M. B. M.²,Martínez-Cerón Sarai¹,Santos da Silva Marcelo³⁴,Elias Maria Carolina³⁴,Crispim Marcell²^ORCID,Trujillo-Ferrara José G.¹,Silber Ariel Mariano²

Affiliation:

1. Laboratory of Biochemistry Research, Escuela Superior de Medicina, Instituto Politécnico Nacional, México Plan de San Luis Y Díaz Mirón S/N, Casco de Santo Tomas, Miguel Hidalgo, Mexico City, Mexico

2. Laboratory of Biochemistry of Tryps–LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Cidade Universitária, São Paulo, Brazil

3. Special Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil

4. Centre of Toxins, Immune Response and Cell Signalling–CeTICS, Butantan Institute, São Paulo, Brazil

Abstract

Chagas disease (CD) is a human infection caused by Trypanosoma cruzi . CD was traditionally endemic to the Americas; however, due to migration it has spread to countries where it is not endemic. The current chemotherapy to treat CD induces several side effects, and its effectiveness in the chronic phase of the disease is controversial. In this contribution, substituted phenylbenzothiazole derivatives were synthesized and biologically evaluated as trypanocidal agents against Trypanosoma cruzi .

Funder

Secretaria de Investigación y Post-Grado del Instituto Politécnico Nacional

United Kingdom Research and Innovation - GCRF

Red Macronunivarsidades

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Consejo Nacional de Ciencia y Tecnología

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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