Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration

Author:

Fan Wei123,Gao Xiu Kui123,Rao Xi Sheng123,Shi Yin Pu123,Liu Xiao Ceng123,Wang Fei Ya4,Liu Yu Fen123,Cong Xiao Xia123,He Min Yi123,Xu Shui Bo123,Shen Wei Liang123,Shen Yue12,Yan Shi Gui12,Luo Yan12,Low Boon Chuan5,Ouyang Hongwei36,Bao Zhang7,Zheng Li Ling1236,Zhou Yi Ting1236ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou, China

2. Department of Orthopaedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

3. Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China

4. Department of Pathology, Hospital of Pingdingshan Coal Industry Group, Pingdingshan, China

5. Mechanobiology Institute, Department of Biological Sciences, National University of Singapore, Singapore, Singapore

6. China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China

7. Department of Respiratory Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Abstract

The regenerative process of injured muscle is dependent on the fusion and differentiation of myoblasts derived from muscle stem cells. Hsp70 is important for maintaining skeletal muscle homeostasis and regeneration, but the precise cellular mechanism remains elusive.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Science and Technology Department of Zhejiang Province

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

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