Mutations in a 23S rRNA Gene of Chlamydia trachomatis Associated with Resistance to Macrolides-Reference-Cited by-同舟云学术

Mutations in a 23S rRNA Gene of Chlamydia trachomatis Associated with Resistance to Macrolides

Published:2004-04 Issue:4 Volume:48 Page:1347-1349
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Misyurina O. Y.¹,Chipitsyna E. V.²,Finashutina Y. P.¹,Lazarev V. N.¹³,Akopian T. A.³,Savicheva A. M.²,Govorun V. M.¹³

Affiliation:

1. Research Institute of Physico-Chemical Medicine, Russian Federation Ministry of Health

2. The D. O. Ott Research Institute of Obstetrics and Gynaecology, Russian Academy of Medical Sciences, Saint-Petersburg, Russia

3. Lytech Ltd., Moscow

Abstract

ABSTRACT For six clinical isolates of Chlamydia trachomatis , in vitro susceptibility to erythromycin, azithromycin, and josamycin has been determined. Four isolates were resistant to all the antibiotics and had the mutations A2058C and T2611C ( Escherichia coli numbering) in the 23S rRNA gene. All the isolates had mixed populations of bacteria that did and did not carry 23S rRNA gene mutations.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.4.1347-1349.2004

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