Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants-Reference-Cited by-同舟云学术

Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

Published:2003-07-15 Issue:14 Volume:185 Page:4276-4279
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Berisio Rita¹,Harms Joerg¹,Schluenzen Frank¹,Zarivach Raz²,Hansen Harly A. S.¹,Fucini Paola³,Yonath Ada²

Affiliation:

1. Max-Planck-Research Unit for Ribosomal Structure, Hamburg

2. Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel

3. Max-Planck-Institute for Molecular Genetics, Berlin, Germany

Abstract

ABSTRACT The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.185.14.4276-4279.2003

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