Molecular Analysis of Metallo-β-Lactamase Gene bla SPM-1 -Surrounding Sequences from Disseminated Pseudomonas aeruginosa Isolates in Recife, Brazil-Reference-Cited by-同舟云学术

Molecular Analysis of Metallo-β-Lactamase Gene bla SPM-1 -Surrounding Sequences from Disseminated Pseudomonas aeruginosa Isolates in Recife, Brazil

Published:2004-04 Issue:4 Volume:48 Page:1406-1409
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Poirel Laurent¹,Magalhaes Marcelo²,Lopes Miguel²,Nordmann Patrice¹

Affiliation:

1. Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France

2. Department of Tropical Medicine, Federal University of Pernambuco, Recife, Brazil

Abstract

ABSTRACT The spread of clonally related carbapenem-resistant Pseudomonas aeruginosa producing the metallo-β-lactamase SPM-1 was found in Recife, Brazil. Upstream of bla SPM-1 , a novel common region (CR4) was identified, comprising an open reading frame, orf495 , whose product shares significant identity with putative recombinases, such as Orf513. CR4 may be responsible for mobilization and expression of bla SPM-1 .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.4.1406-1409.2004

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