Effect of Cell Culture Conditions on the Anticytomegalovirus Activity of Maribavir-Reference-Cited by-同舟云学术

Effect of Cell Culture Conditions on the Anticytomegalovirus Activity of Maribavir

Published:2006-07 Issue:7 Volume:50 Page:2557-2559
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chou Sunwen¹,Van Wechel Laura C.¹,Marousek Gail I.¹

Affiliation:

1. Medical and Research Services, VA Medical Center and Oregon Health & Science University, Portland, Oregon

Abstract

ABSTRACT The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00207-06

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