Prior Antibacterial Peptide-Mediated Inhibition of Protein Folding in Bacteria Mutes Resistance Enzymes-Reference-Cited by-同舟云学术

Prior Antibacterial Peptide-Mediated Inhibition of Protein Folding in Bacteria Mutes Resistance Enzymes

Published:2006-09 Issue:9 Volume:50 Page:3146-3149
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Otvos Laszlo¹²,de Olivier Inacio Vanessa³,Wade John D.⁴,Cudic Predrag³

Affiliation:

1. Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania 19122

2. The Wistar Institute, Philadelphia, Pennsylvania 19104

3. Florida Atlantic University, Boca Raton, Florida 33431

4. Howard Florey Institute, Parkville, 3052 Victoria, Australia

Abstract

ABSTRACT The antimicrobial activity of amoxicillin against TEM-1-expressing strains could be fully recovered when bacteria were preincubated with sublethal doses of an antibacterial peptide derivative. Assays with the simultaneous administration of antibiotics or synergy assays with kanamycin or ciprofloxacin, where resistance development does not involve properly folded proteins, failed to yield similar results.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00205-06

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