Affiliation:
1. Department of Bacteriology, Indiana University, Bloomington, Indiana
Abstract
Brock, Thomas
D. (Indiana University, Bloomington)
and Joseph M. Davie
. Probable identity of a group D hemolysin with a bacteriocine. J. Bacteriol.
86:
708–712. 1963.—All strains of
Streptococcus zymogenes
(
S. faecalis
var.
zymogenes
) produce a bacteriocine which is active against lactic acid bacteria and most other grampositive bacteria. Mutants which have lost the hemolytic characteristic lose at the same time their bacteriocine-producing ability. A strain which was resistant to the bacteriocine but which was nonhemolytic and nonbacteriocinogenic was irradiated, and two hemolytic mutants were isolated from it. These mutants were also bacteriocinogenic. Thus, the two activities are gained or lost together by mutation. Both activities are destroyed by chloroform vapors and are antagonized by lecithin. Both activities are destroyed at the same rate by treatment at 45 C under mildly acid conditions, and both activities are stable when heated in agar. The two activities are produced in parallel during the growth cycle, and disappear in parallel. The possible ecological role of a substance which is both a hemolysin and a bacteriocine is discussed.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference5 articles.
1. BERNHEIMER A. W. 1954. Streptolysins and their inhibitors p. 21. In M. McCarty [ed.] Streptococcal infections. Columbia University Press New York.
2. Survey of the bacteriocines of enterococci;BROCK T. D.;J. Bacteriol.,1963
3. Titration and partial characterization of a soluble hemolysin of a group D streptococcus;IRWIN J.;J. Bacteriol.,1958
4. Studies on streptococci. III. New antibiotic substances produced by beta hemolytic streptococci;SHERWOOD N. B.;J. Infect. Diseases,1949
5. Antibiotic activity of hemolytic enterococci;STARK J. M.;Lancet,1960
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