Aromatic Side Chain at Position 412 of SERINC5 Exerts Restriction Activity toward HIV-1 and Other Retroviruses-Reference-Cited by-同舟云学术

Aromatic Side Chain at Position 412 of SERINC5 Exerts Restriction Activity toward HIV-1 and Other Retroviruses

Published:2021-08-25 Issue:18 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tan Toong Seng¹,Toyoda Mako¹,Tokunaga Kenzo¹²,Ueno Takamasa¹^ORCID

Affiliation:

1. Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

2. Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan

Abstract

The host protein SERINC5 is incorporated into progeny virions of certain retroviruses and restricts the infectivity of these viruses or sensitizes the envelope glycoprotein to a class of neutralizing antibodies. However, how and which part of SERINC5 engages with the diverse array of retroviral envelopes and exerts its antiretroviral functions remain elusive.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00634-21

Reference39 articles.

1. Serinc, an Activity-regulated Protein Family, Incorporates Serine into Membrane Lipid Synthesis

2. HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation