Affiliation:
1. Department of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, Syracuse, New York, USA
Abstract
SUMMARY
Homologous recombination is a universal process, conserved from bacteriophage to human, which is important for the repair of double-strand DNA breaks. Recombination in mitochondrial DNA (mtDNA) was documented more than 4 decades ago, but the underlying molecular mechanism has remained elusive. Recent studies have revealed the presence of a Rad52-type recombination system of bacteriophage origin in mitochondria, which operates by a single-strand annealing mechanism independent of the canonical RecA/Rad51-type recombinases. Increasing evidence supports the notion that, like in bacteriophages, mtDNA inheritance is a coordinated interplay between recombination, repair, and replication. These findings could have profound implications for understanding the mechanism of mtDNA inheritance and the generation of mtDNA deletions in aging cells.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology,Infectious Diseases
Reference236 articles.
1. Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine;Wallace DC;Annu. Rev. Biochem.,2007
2. The organization and inheritance of the mitochondrial genome;Chen XJ;Nat. Rev. Genet.,2005
3. Mammalian mitochondrial nucleoids: organizing an independently minded genome;Holt IJ;Mitochondrion,2007
4. Mitochondrial DNA nucleoid structure;Bogenhagen DF;Biochim. Biophys. Acta,2011
5. Functional organization of mammalian mitochondrial DNA in nucleoids: history, recent developments, and future challenges;Spelbrink JN;IUBMB Life,2010
Cited by
74 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献