Identification of a New Quaternary Neutralizing Epitope on Human Immunodeficiency Virus Type 1 Virus Particles-Reference-Cited by-同舟云学术

Identification of a New Quaternary Neutralizing Epitope on Human Immunodeficiency Virus Type 1 Virus Particles

Published:2005-04-15 Issue:8 Volume:79 Page:5232-5237
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gorny Miroslaw K.¹,Stamatatos Leonidas²,Volsky Barbara¹,Revesz Kathy³,Williams Constance¹,Wang Xiao-Hong³,Cohen Sandra¹,Staudinger Robert³,Zolla-Pazner Susan¹³

Affiliation:

1. Department of Pathology, New York University School of Medicine

2. Seattle Biomedical Research Institute, Seattle, Washington

3. Research Enhancement Award Program, Veterans Affairs New York Harbor Healthcare System, New York, New York

Abstract

ABSTRACT The selection of human monoclonal antibodies (MAbs) specific for human immunodeficiency virus (HIV) type 1 by binding assays may fail to identify Abs to quaternary epitopes on the intact virions. The HIV neutralization assay was used for the selection of human MAb 2909, which potently neutralizes SF162 and recognizes an epitope on the virus surface but not on soluble proteins. Three regions of gp120, the V2 and V3 loops and the CD4 binding domain, contribute to the epitope recognized by MAb 2909. The existence of such a unique MAb, which defines a complex epitope formed by a quaternary structure, suggests that there may be other new neutralizing HIV epitopes to target with vaccines.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.79.8.5232-5237.2005

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