Cloning and Sequence of the Gene Encoding a Novel Cefotaxime-Hydrolyzing β-Lactamase (CTX-M-9) from Escherichia coli in Spain-Reference-Cited by-同舟云学术

Cloning and Sequence of the Gene Encoding a Novel Cefotaxime-Hydrolyzing β-Lactamase (CTX-M-9) from Escherichia coli in Spain

Published:2000-07 Issue:7 Volume:44 Page:1970-1973
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sabaté Montserrat¹,Tarragó Raül²,Navarro Ferran¹,Miró Elisenda¹,Vergés Clara¹,Barbé Jordi²,Prats Guillermo¹

Affiliation:

1. Departament de Microbiologia, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma 08025 Barcelona,1 and

2. Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, 08193 Bellaterra,2 Spain

Abstract

ABSTRACT A new CTX-M-type β-lactamase (CTX-M-9) has been cloned from a clinical cefotaxime-resistant Escherichia coli strain. Despite the close identity that exists between the CTX-M-9 and Toho-2 β-lactamases (88%), the 35 amino acids located between residues Ala-185 and Ala-219 are totally different in both enzymes. Outside of this region there are only six amino acids substitutions between both proteins.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.7.1970-1973.2000

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