UV mutagenesis in Salmonella typhimurium is umuDC dependent despite the presence of samAB-Reference-Cited by-同舟云学术

UV mutagenesis in Salmonella typhimurium is umuDC dependent despite the presence of samAB

Published:1992-05 Issue:9 Volume:174 Page:2809-2815
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Koch W H¹,Cebula T A¹,Foster P L¹,Eisenstadt E¹

Affiliation:

1. Molecular Biology Branch, Food and Drug Administration, Washington, D.C. 20204.

Abstract

We investigated the role of the umuDC and samAB operons in the UV mutability of Salmonella typhimurium. umuDC is located on the chromosome, whereas samAB resides on the virulence plasmid pSLT. Using allele replacement and plasmid curing techniques, we found that UV mutability was eliminated when any of three different umuDC alleles (umuD1, umuC1, or umuD1 umuC1) were on the chromosome even when samAB was present. We conclude that samAB normally does not complement umuDC function in S. typhimurium.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.174.9.2809-2815.1992

Reference44 articles.

1. Evidence for two functional gal promoters in intact Eschenichia coli cells;Aiba H.;J. Biol. Chem.,1981

2. Bleomycin-resistance gene derived from the transposon Tn 5 confers selective advantage to Eschenichia coli K-12;Blot M.;Proc. Natl. Acad. Sci. USA,1991

3. Gene replacement and retrieval with recombinant M13mp bacteriophages;Blum P.;J. Bacteriol.,1989

4. Positive selection for loss of tetracycline resistance;Bochner B. R.;J. Bacteriol.,1980

5. UmuD mutagenesis protein of Escherichia coli: overproduction, purification and cleavage by RecA;Burckhardt S. E.;Proc. Natl. Acad. Sci. USA,1988

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Formation of an F′ Plasmid by Recombination between Imperfectly Repeated Chromosomal Rep Sequences: a Closer Look at an Old Friend (F′ 128 pro lac );Journal of Bacteriology;2003-01-15

2. Phenotypes of lexA Mutations in Salmonella enterica : Evidence for a Lethal lexA Null Phenotype Due to the Fels-2 Prophage;Journal of Bacteriology;2002-11-15

3. Identification of mucAB-like homologs on two IncT plasmids, R394 and Rts-1;Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis;2000-12

4. Regulation of the rulAB Mutagenic DNA Repair Operon of Pseudomonas syringae by UV-B (290 to 320 Nanometers) Radiation and Analysis of rulAB -Mediated Mutability In Vitro and In Planta;Journal of Bacteriology;2000-11

5. Virulence and mutation rates ofSalmonella typhimuriumstrains with increased mutagenic strength in a mouse model;FEMS Microbiology Letters;2000-06