Utilizing Two Borrelia bavariensis Isolates Naturally Lacking the PFam54 Gene Array To Elucidate the Roles of PFam54-Encoded Proteins

Author:

Rollins Robert E.1ORCID,Wülbern Janna12,Röttgerding Florian3,Nowak Tristan A.45,Hepner Sabrina6,Fingerle Volker6,Margos Gabriele6,Lin Yi-Pin45ORCID,Kraiczy Peter3,Becker Noémie S.1ORCID

Affiliation:

1. Division of Evolutionary Biology, Faculty of Biology, LMU Munich, Planegg-Martinsried, Germany

2. Evolutionary Ecology and Genetics, Faculty of Biology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany

3. Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany

4. Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA

5. Department of Biomedical Sciences, State University of New York at Albany, Albany, New York, USA

6. National Reference Centre for Borrelia, Bavarian Health and Food Safety Authority, Oberschleissheim, Germany

Abstract

To establish infections, Lyme borreliae utilize various means to overcome the host’s immune system. Proteins encoded by the PFam54 gene array play a role in spirochete survival in vitro and in vivo .

Funder

Robert Koch Institut

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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