Susceptibility Profiles, Molecular Epidemiology, and Detection of KPC-Producing Escherichia coli Isolates from the New York City Vicinity

Author:

Landman David1,Urban Carl2,Bäcker Martin1,Kelly Paul1,Shah Neha1,Babu Elizabeth1,Bratu Simona1,Quale John1

Affiliation:

1. Division of Infectious Diseases, SUNY-Downstate, Brooklyn, New York

2. Infectious Diseases Section, New York Hospital Queens, Flushing, New York

Abstract

ABSTRACT The detection of Enterobacteriaceae carrying the carbapenemase KPC has been problematic. Thirty isolates of KPC-possessing Escherichia coli were gathered from hospitals in New York City and Connecticut. The imipenem, meropenem, doripenem, and ertapenem MIC 50 values were 4, 2, 1, and 4 μg/ml, respectively. Over half of the isolates belonged to a single ribotype. Using an ertapenem breakpoint of 0.25 μg/ml would efficiently detect these isolates.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference21 articles.

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3. Bratu, S., D. Landman, R. Haag, R. Recco, A. Eramo, M. Alam, and J. Quale. 2005. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City. A new threat to our antibiotic armamentarium. Arch. Intern. Med. 165 : 1430-1435.

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5. Centers for Disease Control and Prevention. 2009. Modified Hodge test for carbapenemase detection in Enterobacteriaceae. CDC Atlanta GA. http://www.cdc.gov/ncidod/dhqp/pdf/ar/HodgeTest_Carbapenemase_Enterobacteriaceae.pdf .

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