In Vivo Imaging of the Buccal Mucosa Shows Loss of the Endothelial Glycocalyx and Perivascular Hemorrhages in Pediatric Plasmodium falciparum Malaria-Reference-Cited by-同舟云学术

In Vivo Imaging of the Buccal Mucosa Shows Loss of the Endothelial Glycocalyx and Perivascular Hemorrhages in Pediatric Plasmodium falciparum Malaria

Published:2020-02-20 Issue:3 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lyimo Eric¹,Haslund Lars Emil²,Ramsing Thomas²,Wang Christian William³⁴,Efunshile Akinwale Michael⁵,Manjurano Alphaxard¹,Makene Victor⁶,Lusingu John⁷,Theander Thor Grundtvig³⁴,Kurtzhals Jørgen Anders Lindholm³⁸,Paulsen Rasmus²,Hempel Casper⁹

Affiliation:

1. National Institute for Medical Research (NIMR), Mwanza, Tanzania

2. Department for Computer Sciences, Technical University of Denmark, Kongens Lyngby, Denmark

3. Centre for Medical Parasitology, Department for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

4. Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

5. Department of Medical Microbiology, Federal Teaching Hospital/Ebonyi State University, Abakaliki, Nigeria

6. University of Dar es Salaam, Dar es Salaam, Tanzania

7. National Institute for Medical Research (NIMR), Tanga, Tanzania

8. Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark

9. Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark

Abstract

Severe malaria is mostly caused by Plasmodium falciparum, resulting in considerable, systemic inflammation and pronounced endothelial activation. The endothelium forms an interface between blood and tissue, and vasculopathy has previously been linked with malaria severity. We studied the extent to which the endothelial glycocalyx that normally maintains endothelial function is involved in falciparum malaria pathogenesis by using incident dark-field imaging in the buccal mucosa.

Funder

Ministry of Science, Innovation and Higher Education | Danish Agency for Science and Higher Education

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00679-19

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