Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria

Author:

Higgins Sarah J.123,Purcell Lisa A.4,Silver Karlee L.25,Tran Vanessa2,Crowley Valerie2,Hawkes Michael26,Conroy Andrea L.2,Opoka Robert O.7,Hay John G.8,Quaggin Susan E.9,Thurston Gavin4,Liles W. Conrad10,Kain Kevin C.12

Affiliation:

1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

2. Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, and the Tropical Disease Unit, Department of Medicine, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

3. Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

4. Regeneron Pharmaceuticals Inc, Tarrytown, NY 10591, USA.

5. Grand Challenges Canada, Toronto, Ontario M5G 1L7, Canada.

6. Department of Pediatrics, University of Alberta, Edmonton, Alberta T6G 1C9, Canada.

7. Department of Paediatrics and Child Health, Mulago Hospital and Makerere University, Kampala 7051, Uganda.

8. New York University School of Medicine, New York, NY 10006, USA.

9. Feinberg Cardiovascular Research Institute and Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

10. Departments of Medicine, Pathology, Pharmacology and Global Health, University of Washington, Seattle, WA 98195, USA.

Abstract

Angiopoietin-1 is dysregulated in pediatric severe malaria, and targeting it prevents vascular dysfunction and death in a mouse model of cerebral malaria.

Funder

Canadian Institutes of Health Research

CIHR Foundation

Canada Research Chairs

CIHR Graduate Scholarship

Tesari Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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