In Staphylococcus aureus, the Particulate State of the Cell Envelope Is Required for the Efficient Induction of Host Defense Responses

Author:

Kim ByungHyun1,Jiang TingTing1,Bae Jun-Hyun1,Yun Hye Su1,Jang Seong Han1,Kim Jung Hyun1,Kim Jae Deog1,Hur Jin-Hoe2,Shibata Kensuke3,Kurokawa Kenji4,Jung Yunjin1,Peschel Andreas5ORCID,Bae Taeok6ORCID,Lee Bok Luel1

Affiliation:

1. Host Defense Protein Laboratory, College of Pharmacy, Pusan National University, Busan, Republic of Korea

2. UNIST-Olympus Biomed Imaging Center, UNIST, Ulsan, Republic of Korea

3. Department of Microbiology and Immunology, Yamaguchi University, Graduate School of Medicine, Yamaguchi, Japan

4. Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki, Japan

5. Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany

6. Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, Indiana, USA

Abstract

Upon microbial infection, host immune cells recognize bacterial cell envelope components through cognate receptors. Although bacterial cell envelope components function as innate immune molecules, the role of the physical state of the bacterial cell envelope (i.e., particulate versus soluble) in host immune activation has not been clearly defined.

Funder

Indiana University

Pusan National University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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