Development of Combination Vaccine Conferring Optimal Protection against Six Pore-Forming Toxins of Staphylococcus aureus-Reference-Cited by-同舟云学术

Development of Combination Vaccine Conferring Optimal Protection against Six Pore-Forming Toxins of Staphylococcus aureus

Published:2021-09-16 Issue:10 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Zhang QingFeng¹,Jiang TingTing¹,Mao Xinrui¹,Kim Jae Deog¹,Ahn Dong Ho²,Jung Yunjin¹,Bae Taeok³^ORCID,Lee Bok Luel¹^ORCID

Affiliation:

1. Host Defense Protein Laboratory, College of Pharmacy, Pusan National University, Busan, Republic of Korea

2. New Drug Development Section, Clips Company, Seoul, Republic of Korea

3. Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, Indiana, USA

Abstract

In the Gram-positive pathogen Staphylococcus aureus , pore-forming toxins (PFTs), such as leukocidins and hemolysins, play prominent roles in staphylococcal pathogenesis by killing host immune cells and red blood cells (RBCs). However, it remains unknown which combination of toxin antigens would induce the broadest protective immune response against those toxins.

Funder

HHS | NIH | OSC | Common Fund

Indiana Clinical and Translational Sciences Institute

Korea Institute for Advancement of Technology

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00342-21

Reference36 articles.