MODS-Wayne, a Colorimetric Adaptation of the Microscopic-Observation Drug Susceptibility (MODS) Assay for Detection of Mycobacterium tuberculosis Pyrazinamide Resistance from Sputum Samples-Reference-Cited by-同舟云学术

MODS-Wayne, a Colorimetric Adaptation of the Microscopic-Observation Drug Susceptibility (MODS) Assay for Detection of Mycobacterium tuberculosis Pyrazinamide Resistance from Sputum Samples

Published:2019-02 Issue:2 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Alcántara Roberto¹,Fuentes Patricia¹,Antiparra Ricardo¹,Santos Marco¹,Gilman Robert H.²,Kirwan Daniela E.³,Zimic Mirko¹,Sheen Patricia¹

Affiliation:

1. Laboratorio de Bioinformática y Biología Molecular, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru

2. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

3. Institute for Infection and Immunity, St. George’s, University of London, London, United Kingdom

Abstract

Although pyrazinamide (PZA) is a key component of first- and second-line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) and over 90% of extensively drug-resistant tuberculosis (XDR-TB) strains are also PZA resistant.

Funder

Wellcome Trust Intermediate Fellowship

FONDECYT

Grand Challenges Canada

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01162-18

Reference42 articles.

1. The curious characteristics of pyrazinamide: a review;Zhang Y;Int J Tuberc Lung Dis,2003