Equine Herpesvirus 1 Utilizes a Novel Herpesvirus Entry Receptor-Reference-Cited by-同舟云学术

Equine Herpesvirus 1 Utilizes a Novel Herpesvirus Entry Receptor

Published:2005-03 Issue:5 Volume:79 Page:3169-3173
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Frampton Arthur R.¹,Goins William F.¹,Cohen Justus B.¹,von Einem Jens²,Osterrieder Nikolaus²,O'Callaghan Dennis J.³,Glorioso Joseph C.¹

Affiliation:

1. Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

2. Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York

3. Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana

Abstract

ABSTRACT The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor. As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.79.5.3169-3173.2005

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