Copper Intoxication in Group B Streptococcus Triggers Transcriptional Activation of the cop Operon That Contributes to Enhanced Virulence during Acute Infection-Reference-Cited by-同舟云学术

Copper Intoxication in Group B Streptococcus Triggers Transcriptional Activation of the cop Operon That Contributes to Enhanced Virulence during Acute Infection

Published:2021-09-08 Issue:19 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Sullivan Matthew J.¹²^ORCID,Goh Kelvin G. K.¹²^ORCID,Gosling Dean¹,Katupitiya Lahiru¹,Ulett Glen C.¹²^ORCID

Affiliation:

1. School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, Queensland, Australia

2. Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

Abstract

Understanding how bacteria manage cellular levels of metal ions, such as copper, helps to explain how microbial cells can survive in different stressful environments. We show the opportunistic pathogen group B streptococcus (GBS) achieve homeostasis of intracellular copper through the activities of the genes that comprise the cop operon, and we describe how this helps GBS survive in stressful environments, including in the mammalian host during systemic disseminated infection.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00315-21

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