Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies-Reference-Cited by-同舟云学术

Copper Efflux System Required in Murine Lung Infection by Haemophilus influenzae Composed of a Canonical ATPase Gene and Tandem Chaperone Gene Copies

Published:2023-05-16 Issue:5 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Wong Sandy M.¹,Gawronski Jeffrey²,Akerley Brian J.¹³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, USA

2. Department of Microbiology and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

3. Department of Cell and Molecular Biology, Center for Immunology and Microbial Research, University of Mississippi Medical Center, Jackson, Mississippi, USA

Abstract

Copper is an essential micronutrient but is toxic at high concentrations. In Haemophilus influenzae mechanisms of copper resistance and its role in pathogenesis are unknown; however, our previous genetic screen by transposon insertion-site sequencing implicated a putative cation transporting ATPase ( copA ) in survival in a mouse lung infection model.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00091-23

Reference109 articles.

1. Role of nontypeable Haemophilus influenzae in pediatric respiratory tract infections

2. Persistent Colonization byHaemophilus influenzaein Chronic Obstructive Pulmonary Disease

3. Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule

4. Insights on persistent airway infection by non-typeable Haemophilus influenzae in chronic obstructive pulmonary disease

5. Current and Emerging Therapies to Combat Cystic Fibrosis Lung Infections

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