Analysis of a Corynebacterium glutamicum hom gene coding for a feedback-resistant homoserine dehydrogenase-Reference-Cited by-同舟云学术

Analysis of a Corynebacterium glutamicum hom gene coding for a feedback-resistant homoserine dehydrogenase

Published:1991-05 Issue:10 Volume:173 Page:3228-3230
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Reinscheid D J¹,Eikmanns B J¹,Sahm H¹

Affiliation:

1. Institut für Biotechnologie, 1 des Forschungszentrums Jülich GmbH, Federal Republic of Germany.

Abstract

From a Corynebacterium glutamicum mutant possessing a homoserine dehydrogenase resistant to feedback inhibition by L-threonine, the corresponding gene (homFBR) was analyzed and compared with the wild-type hom gene. DNA fragment exchange experiments between both genes showed that a 0.23-kb region close to the 3' terminus of homFBR was responsible for deregulation. Nucleotide sequence analysis revealed a single transition from G to A in homFBR leading to replacement of glycine-378 by glutamate in the mutant homoserine dehydrogenase.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.173.10.3228-3230.1991

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