The Application of Corynebacterium glutamicum in l-Threonine Biosynthesis-Reference-Cited by-同舟云学术

The Application of Corynebacterium glutamicum in l-Threonine Biosynthesis

Published:2023-09-08 Issue:9 Volume:9 Page:822
ISSN:2311-5637
Container-title:Fermentation
language:en
Short-container-title:Fermentation

Author:

Duan Min¹,Chen Shuo¹,Liu Xinli¹²,Liu Jianhang¹²,Zhu Deqiang¹²^ORCID

Affiliation:

1. State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China

2. Shandong Provincial Key Laboratory of Microbial Engineering, School of Bioengineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China

Abstract

l-threonine is an essential amino acid in human and animal nutrition. It is widely used in food, medicine, feed, and other fields. The global market scale exceeds 700,000 tons per year. Corynebacterium glutamicum, as a chassis cell for industrial amino acid production, has the advantages of biological safety and strong environmental adaptability, and is a potential strain for the efficient production of l-threonine. This article systematically reviewed the function and application of l-threonine, the pathway of C. glutamicum to synthesize l-threonine, and the use of metabolic engineering technology to improve the production of l-threonine.

Funder

Qilu University of Technology, Shandong Academy of Sciences

Shandong Province Science and Technology SMES Innovation Ability Improvement Project

Dezhou Major Science and Technology Innovation Project and Rizhao Key Research and Development Plan

Publisher

MDPI AG

Subject

Plant Science,Biochemistry, Genetics and Molecular Biology (miscellaneous),Food Science

Link

https://www.mdpi.com/2311-5637/9/9/822/pdf

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