Antimicrobial Activities of Daptomycin, Vancomycin, and Oxacillin in Human Monocytes and of Daptomycin in Combination with Gentamicin and/or Rifampin in Human Monocytes and in Broth against Staphylococcus aureus-Reference-Cited by-同舟云学术

Antimicrobial Activities of Daptomycin, Vancomycin, and Oxacillin in Human Monocytes and of Daptomycin in Combination with Gentamicin and/or Rifampin in Human Monocytes and in Broth against Staphylococcus aureus

Published:2007-04 Issue:4 Volume:51 Page:1559-1562
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Baltch Aldona L.¹²,Ritz William J.¹²,Bopp Lawrence H.¹,Michelsen Phyllis B.¹²,Smith Raymond P.¹²

Affiliation:

1. Infectious Disease Research Laboratory, Stratton Veterans Affairs Medical Center

2. Albany Medical College, Albany, New York

Abstract

ABSTRACT We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of daptomycin, gentamicin, and rifampin was most effective intracellularly, while daptomycin plus gentamicin and the three-drug combination were most effective extracellularly, completely eliminating viable Staphylococcus aureus .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00973-06

Reference17 articles.

1. Pharmacodynamic Evaluation of the Intracellular Activities of Antibiotics against Staphylococcus aureus in a Model of THP-1 Macrophages

2. Brouillette, E., G. Grondin, L. Shkreta, P. Lacasse, and B. G. Talbot. 2003. In vivo and in vitro demonstration that Staphylococcus aureus is an intracellular pathogen in the presence or absence of fibronectin-binding proteins. Microb. Pathog.35:159-168.

3. Carlyn, C. J., A. L. Baltch, W. J. Ritz, and R. P. Smith. 2006. Daptomycin in the treatment of persistent bacteremia with invasive complications caused by a small colony variant of methicillin-resistant Staphylococcus aureus in an orthopedic patient. Infect. Dis. Clin. Pract.14:394-398.

4. Carryn, S., H. Chanteux, C. Seral, M.-P. Mingeot-Leclercq, F. Van Bambeke, and P. M. Tulkens. 2003. Intracellular pharmacodynamics of antibiotics. Infect. Dis. Clin. N. Am.17:615-634.

5. Cilli, F., S. Aydemir, and A. Tunger. 2006. In vitro activity of daptomycin alone and in combination with various antimicrobials against Gram-positive cocci. J. Chemother.18:27-32.

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