Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus-Reference-Cited by-同舟云学术

Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus

Published:2021-08-17 Issue:9 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ganapathy Uday S.¹,Lan Tian²,Krastel Philipp³,Lindman Marissa¹,Zimmerman Matthew D.¹,Ho HsinPin¹,Sarathy Jansy P.¹,Evans Joanna C.¹,Dartois Véronique¹⁴^ORCID,Aldrich Courtney C.²,Dick Thomas¹⁴⁵^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota, USA

3. Natural Products Unit, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland

4. Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA

5. Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA

Abstract

Rifampicin is an effective drug for treating tuberculosis (TB) but is not used to treat Mycobacterium abscessus infections due to poor in vitro activity. While rifabutin, another rifamycin, has better anti- M. abscessus activity, its activity is far from the nanomolar potencies of rifamycins against Mycobacterium tuberculosis .

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00978-21

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