Increased Mortality in Mice following Immunoprophylaxis Therapy with High Dosage of Nicotinamide in Burkholderia Persistent Infections-Reference-Cited by-同舟云学术

Increased Mortality in Mice following Immunoprophylaxis Therapy with High Dosage of Nicotinamide in Burkholderia Persistent Infections

Published:2019-01 Issue:1 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Micheva-Viteva Sofiya N.¹,Ross Brittany N.²,Gao Jun¹,Adikari Samantha¹,Zhang Pengfei³,Mourant Judith R.¹,Wu Terry H.⁴,Werner James H.³,Torres Alfredo G.²,Hong-Geller Elizabeth¹

Affiliation:

1. Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

2. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

3. Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

4. University of New Mexico Health Sciences Center, Department of Internal Medicine, Albuquerque, New Mexico, USA

Abstract

Bacterial persistence, known as noninherited antibacterial resistance, is a factor contributing to the establishment of long-lasting chronic bacterial infections. In this study, we examined the ability of nicotinamide (NA) to potentiate the activity of different classes of antibiotics against Burkholderia thailandensis persister cells.

Funder

DOD | Defense Threat Reduction Agency

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00592-18

Reference45 articles.

1. Biofilms and Planktonic Cells of Pseudomonas aeruginosa Have Similar Resistance to Killing by Antimicrobials

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3. Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation