The Recombinant Phage Lysin LysK Has a Broad Spectrum of Lytic Activity against Clinically Relevant Staphylococci, Including Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

The Recombinant Phage Lysin LysK Has a Broad Spectrum of Lytic Activity against Clinically Relevant Staphylococci, Including Methicillin-Resistant Staphylococcus aureus

Published:2005-10-15 Issue:20 Volume:187 Page:7161-7164
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

O'Flaherty S.¹²³,Coffey A.⁴,Meaney W.²,Fitzgerald G. F.³⁵,Ross R. P.¹⁵

Affiliation:

1. Dairy Products Research Centre, Teagasc, Moorepark, Fermoy, Co. Cork, Ireland

2. Dairy Production Research Centre, Teagasc, Moorepark, Fermoy, Co. Cork, Ireland

3. Department of Microbiology, University College, Cork, Ireland

4. Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland

5. Alimentary Pharmabiotic Centre, Cork, Ireland

Abstract

ABSTRACT This study concerns the cloning, characterization, and expression of the lysin (LysK) from staphylococcal phage K in Lactococcus lactis . Lactococcal lysates containing recombinant LysK were found to inhibit a range of different species of staphylococci isolated from bovine and human infection sources, including methicillin-resistant Staphylococcus aureus . LysK thus has potential as an antimicrobial for applications in the prevention and/or treatment of infections caused by staphylococci.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.187.20.7161-7164.2005

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