Sustained-Release Formulation of Doxycycline Hyclate for Prophylaxis of Tick Bite Infection in a Murine Model of Lyme Borreliosis-Reference-Cited by-同舟云学术

Sustained-Release Formulation of Doxycycline Hyclate for Prophylaxis of Tick Bite Infection in a Murine Model of Lyme Borreliosis

Published:2004-07 Issue:7 Volume:48 Page:2697-2699
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zeidner N. S.¹,Brandt K. S.¹,Dadey E.²,Dolan M. C.¹,Happ C.¹,Piesman J.¹

Affiliation:

1. Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522

2. Atrix Laboratories, Fort Collins, Colorado 80525

Abstract

ABSTRACT The prophylactic potential of a single injection of sustained-release doxycycline hyclate (Atridox) was compared to that of a single oral dose of doxycycline hyclate in a murine model of Lyme borreliosis. Prophylaxis, as measured by the lack of cultivable spirochetes and demonstrable pathology, was noted for 43% of orally treated mice; in contrast, the sustained-release doxycycline hyclate completely protected mice from infection and resultant pathology.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.7.2697-2699.2004

Reference22 articles.

1. Axisa, B., A. R. Naylor, P. R. F. Bell, and M. M. Thompson. 2000. Simple and reliable method of doxycycline determination in human plasma and biological tissues. J. Chromatogr.744:359-365.

2. Burkot, T. R., B. S. Schneider, N. Pieniazek, C. M. Happ, J. S. Rutherford, S. G. Slemenda, E. Hoffmeister, G. O. Maupin, and N. S. Zeidner. 2000. Babesia microti and Borrelia burgdorferi transmission by Ixodes spinipalpis ticks among prairie voles, Microtus ochrogaster, in Colorado. Parasitology121:595-599.

3. Centers for Disease Control and Prevention. 2002. Lyme disease—United States, 2000. Morb. Mortal. Wkly. Rep.51:29-31.

4. Hayes, E. B., and J. Piesman. 2003. How can we prevent Lyme disease? N. Engl. J. Med.348:2424-2430.

5. Comparative in vitro and in vivo susceptibilities of the Lyme disease spirochete Borrelia burgdorferi to cefuroxime and other antimicrobial agents

Cited by 38 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rodent-targeted approaches to reduce acarological risk of human exposure to pathogen-infected Ixodes ticks;Ticks and Tick-borne Diseases;2023-03

2. Response to Determination of Oral Doxycycline Efficacy for Clearance of Borrelia burgdorferi Infection;The Journal of Infectious Diseases;2021-10-06

3. Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo;Science Advances;2021-09-03

4. References;Divided Bodies;2020

5. Notes;Divided Bodies;2020