Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo

Author:

Shahini Aref1ORCID,Rajabian Nika1ORCID,Choudhury Debanik1,Shahini Shahryar1ORCID,Vydiam Kalyan2ORCID,Nguyen Thy2,Kulczyk Joseph1ORCID,Santarelli Tyler2ORCID,Ikhapoh Izuagie1,Zhang Yali3ORCID,Wang Jianmin3ORCID,Liu Song3,Stablewski Aimee4ORCID,Thiyagarajan Ramkumar5,Seldeen Kenneth5ORCID,Troen Bruce R.56ORCID,Peirick Jennifer7ORCID,Lei Pedro1,Andreadis Stelios T.1289ORCID

Affiliation:

1. Bioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

2. Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

3. Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY 14260, USA.

4. Gene Targeting and Transgenic Shared Resource, Roswell Park Comprehensive Cancer Center.

5. Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

6. Research Service, VA Western New York Healthcare System, Buffalo, NY 14260, USA.

7. Laboratory Animal Facilities, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

8. Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

9. Center for Cell Gene and Tissue Engineering (CGTE), University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

Abstract

The embryonic factor NANOG reverses aging hallmarks and rejuvenates senescent skeletal muscle progenitors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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