Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coli-Reference-Cited by-同舟云学术

Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coli

Published:1995-10 Issue:10 Volume:39 Page:2359-2363
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Noguchi N¹,Emura A¹,Matsuyama H¹,O'Hara K¹,Sasatsu M¹,Kono M¹

Affiliation:

1. Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.

Abstract

The DNA fragment (3.3 kb) containing the erythromycin resistance determinant was cloned from Escherichia coli Tf481A and sequenced. Deletion and complementation analyses indicated that the expression of high-level resistance to erythromycin requires two genes, mphA and mrx, which encode macrolide 2'-phosphotransferase I and an unidentified hydrophobic protein, respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.39.10.2359

Reference19 articles.

1. Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid;Chang A. C. Y.;J. Bacteriol.,1978

2. Translational initiation in prokaryotes. Annu;Gold L.;Rev. Microbiol.,1981

3. A restriction enzyme map of R-plasmid RP1;Grinsted J.;Plasmid,1977

4. Properties of an R factor which originated in Pseudomonas aeruginosa 1822;Grinsted J.;J. Bacteriol.,1972

5. Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing;Henikoff S.;Gene,1984

Cited by 90 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Functional relay between Mph(A) enzyme and Mrx efflux pump mediates azithromycin resistance, a novel mechanism of bacterial antimicrobial resistance;Drug Resistance Updates;2024-11

2. Sensitive and Specific Loop-Mediated Isothermal Amplification Assays for Detection of Salmonella, CTX-M-1 Group Genes, mph(A), and ermB in Stool and Blood Samples Based on Orange to Green Visible Dye;Foodborne Pathogens and Disease;2024-03-22

3. Microbial diversity characterizations, associated pathogenesis and antimicrobial resistance profiling of Najafgarh drain;Environmental Research;2023-12

4. Modulating Sensitivity of an Erythromycin Biosensor for Precise High-Throughput Screening of Strains with Different Characteristics;ACS Synthetic Biology;2023-05-18

5. Comparative analysis of SilA-laccase mediated degradation of ciprofloxacin, norfloxacin and ofloxacin and interpretation of the possible catalytic mechanism;Journal of Biomolecular Structure and Dynamics;2023-04-25