Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense-Reference-Cited by-同舟云学术

Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense

Published:1990-06 Issue:6 Volume:34 Page:1183-1188
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bacchi C J¹,Nathan H C¹,Livingston T¹,Valladares G¹,Saric M¹,Sayer P D¹,Njogu A R¹,Clarkson A B¹

Affiliation:

1. Haskins Laboratories, Pace University, New York, New York 10038.

Abstract

DL-alpha-Difluoromethylornithine is an enzyme-activated inhibitor of ornithine decarboxylase and an antagonist of polyamine metabolism that has been successful in clinical trials against West African sleeping sickness caused by Trypanosoma brucei gambiense. Its potential for use against the more virulent East African form of the disease, caused by T. brucei rhodesiense, is not certain. We examined 14 East African clinical isolates from the Kenya Trypanosomiasis Research Institute strain bank plus 2 established isolates for susceptibility to DL-alpha-difluoromethylornithine and to standard trypanocides. Seven of 16 strains were partially or totally refractory to DL-alpha-difluoromethylornithine in our test system. Four strains were also refractory to arsenical drugs, and five were refractory to diamidines. The results indicate that other novel agents or combinations of established agents may be needed for chemotherapy of East African disease.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.34.6.1183

Reference30 articles.

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5. Effect of a-difluoromethylornithine on protein synthesis and synthesis of variant-specific glycoprotein (VSG) in Trypanosoma brucei brucei;Bitonti A. J.;Biochem. J.,1988

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