The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History

Author:

P. De Koning HarryORCID

Abstract

With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’: their development, their limitations and the resistance that the parasites developed against them. This retrospective looks back on the remarkable story of chemotherapy against trypanosomiasis, a story that goes back to the very origins and conception of chemotherapy in the first years of the 20 century and is still not finished today.

Publisher

MDPI AG

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Immunology and Microbiology

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5. Mort par hypoglycémie dans les trypanosomiases aiguës;Dubois;CR Soc. Biol.,1928

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