Lactococcus lactis as a Cell Factory for High-Level Diacetyl Production-Reference-Cited by-同舟云学术

Lactococcus lactis as a Cell Factory for High-Level Diacetyl Production

Published:2000-09 Issue:9 Volume:66 Page:4112-4114
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Hugenholtz Jeroen¹,Kleerebezem Michiel¹,Starrenburg Marjo¹,Delcour Jean²,de Vos Willem¹,Hols Pascal¹²

Affiliation:

1. Wageningen Centre for Food Sciences and NIZO Food Research, 6710 BA Ede, The Netherlands,1and

2. Laboratoire de Génétique Moléculaire, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium2

Abstract

ABSTRACT We report the engineering of Lactococcus lactis for the efficient conversion of sugar into diacetyl by combining NADH-oxidase overproduction and α-acetolactate decarboxylase inactivation. Eighty percent of the carbon flux was found to be rerouted via α-acetolactate to the production of diacetyl by preloading the cells with NADH-oxidase before their use as a cell factory.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.66.9.4112-4114.2000

Reference14 articles.

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3. Isolation and properties of Lactococcus lactis subsp. lactis biovar diacetylactis CNRZ 483 mutants producing diacetyl and acetoin from glucose

4. A General Method for Selection of α-Acetolactate Decarboxylase-Deficient Lactococcus lactis Mutants To Improve Diacetyl Formation

5. Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin

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