Use of Bacterial γ-Glutamyltranspeptidase for Enzymatic Synthesis of γ- d -Glutamyl Compounds-Reference-Cited by-同舟云学术

Use of Bacterial γ-Glutamyltranspeptidase for Enzymatic Synthesis of γ- d -Glutamyl Compounds

Published:2003-11 Issue:11 Volume:69 Page:6399-6404
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Suzuki Hideyuki¹,Izuka Shunsuke¹,Minami Hiromichi¹,Miyakawa Nobukazu¹,Ishihara Sayaka¹,Kumagai Hidehiko¹

Affiliation:

1. Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan

Abstract

ABSTRACT An enzymatic method for synthesizing various γ- d -glutamyl compounds efficiently and stereospecifically involving bacterial γ-glutamyltranspeptidase (EC 2.3.2.2) with d -glutamine as a γ-glutamyl donor was developed. With d -glutamine as a γ-glutamyl donor instead of l -glutamine in γ-glutamyltaurine synthesis, by-products such as γ-glutamylglutamine and γ-glutamyl-γ-glutamyltaurine were not synthesized and the yield of γ-glutamyltaurine dramatically increased from 25 to 71%. It was also shown that the purification could be simplified without these γ-glutamyl by-products. The possibility of synthesizing various γ- d -glutamyl compounds was also shown.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.69.11.6399-6404.2003

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