Etest ECVs/ECOFFs for Detection of Resistance in Prevalent and Three Nonprevalent Candida spp. to Triazoles and Amphotericin B and Aspergillus spp. to Caspofungin: Further Assessment of Modal Variability

Author:

Espinel-Ingroff A.1ORCID,Sasso M.2ORCID,Turnidge J.3ORCID,Arendrup M.4ORCID,Botterel F.5,Bourgeois N.6,Bouteille B.7,Canton E.8,Cassaing S.9,Dannaoui E.10ORCID,Dehais M.11,Delhaes L.12,Dupont D.13,Fekkar A.14ORCID,Fuller J.15,Garcia-Effron G.16,Garcia J.17,Gonzalez G. M.18,Govender N. P.19ORCID,Guegan H.20,Guinea J.21ORCID,Houzé S.22,Lass-Flörl C.23ORCID,Pelaez T.24,Forastiero A.25,Lackner M.23,Magobo R.19

Affiliation:

1. VCU Medical Center, Richmond, Virginia, USA

2. MIVEGEC, Université, Montpellier, CHU de Nîmes, CNRS, IRD, Montpellier, France

3. Adelaide Medical School and School of Biological Sciences, University of Adelaide, Adelaide, Australia

4. Unit of Mycology, Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark

5. Unité de Parasitologie-Mycologie, CHU Henri Mondor, APHP, Paris, France

6. MIVEGEC, Université Montpellier, CHU de Montpellier, CNRS, IRD, Montpellier, France

7. Service de Parasitologie-Mycologie, CHU Limoges, Limoges, France

8. Grupo Infección Grave, Instituto Investigación Sanitaria La Fe, Valencia, Spain

9. Service de Parasitologie-Mycologie, CHU Toulouse, Université Paul Sabatier, Toulouse, France

10. Laboratoire de Parasitologie-Mycologie, Département de Microbiologie, Université de Paris, Faculté de Médecine, APHP, Hôpital Européen Georges Pompidou, Paris, France

11. Laboratoire de Parasitologie Mycologie, Rouen, France

12. Service de Parasitologie-Mycologie, CHU Bordeaux, France

13. Hospices Civils de Lyon, Institut des Agents Infectieux, Parasitologie-Mycologie Médicale, Université Lyon 1, Lyon, France

14. AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie-Mycologie, Paris, France

15. Western University, Ontario, Canada

16. Laboratorio de Micología y Diagnóstico Molecular–CONICET, Cátedra de Parasitología y Micología, Fac. Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

17. Hospital Universitario La Paz, Madrid, Spain

18. Universidad Autónoma de Nuevo León, Monterrey, Mexico

19. National Institute for Communicable Diseases, a Division of the National Health Laboratory Service and Faculty of Health Sciences University of Witwatersrand, Johannesburg, South Africa

20. Univ Rennes, CHU, Inserm, Irset (Institut de Recherche en Santé, Environnement et Travail)–UMR_S 1085, Rennes, France

21. Servicio de Microbiología Clínica y Enfermedades Infecciosas-VIH, Hospital General Universitario Gregorio Marañon and Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

22. Université de Paris, UMR 261 MERIT, IRD, Service de Parasitologie, AP-HP, Hôpital Bichat, Paris, France

23. Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria

24. Hospital Universitario Central de Asturias, Fundación para la Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain

25. Servicio de Micologia, Laboratorio de Microbiologia, Hospital Britanico, Buenos Aires, Argentina

Abstract

Susceptibility testing is an important tool in the clinical setting; its utility is based on the availability of categorical endpoints, breakpoints (BPs), or epidemiological cutoff values (ECVs/ECOFFs). CLSI and EUCAST have developed antifungal susceptibility testing, BPs, and ECVs for some fungal species.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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