Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit-Reference-Cited by-同舟云学术

Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit

Published:2023-02-28 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Presente Simona¹,Bonnal Christine²,Normand Anne-Cécile³^ORCID,Gaudonnet Yannick⁴,Fekkar Arnaud³^ORCID,Timsit Jean-François¹⁵^ORCID,Kernéis Solen⁴⁵^ORCID

Affiliation:

1. Medical and infectious diseases ICU, APHP, Bichat hospital, Paris, France

2. Laboratoire de parasitologie mycologie, AP-HP, Hôpital Bichat Claude Bernard, Paris, France

3. Laboratoire de parasitologie mycologie, AP-HP, Hôpital Pitié Salpêtrière, Paris, France

4. Equipe de Prévention du Risque Infectieux, AP-HP, Hôpital Bichat, Paris, France

5. Université Paris Cité, INSERM, IAME, Paris, France

Abstract

We report the first identification of a fluconazole-resistant Candida parapsilosis (FR- Cp ) strain in our hospital, which subsequently caused an outbreak involving 17 patients (12 deaths) within a 26-bed French intensive care unit. Microsatellite genotyping confirmed that all FR- Cp isolates belonged to the same clone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01130-22

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