Pharmacology of Amikacin in Humans

Author:

Bodey Gerald P.1,Valdivieso Manuel1,Feld Ronald1,Rodriguez Victorio1

Affiliation:

1. Department of Developmental Therapeutics, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

Abstract

Amikacin is a new aminoglycoside antibiotic which is active in vitro against most isolates of gram-negative bacilli. A dose of 300 mg/m 2 intramuscularly produced a highest mean serum concentration of 25.4 μg/ml with a mean serum concentration of 3.1 μg/ml at 8 h. The same dose intravenously produced a highest mean serum concentration of 52.4 μg/ml with a mean serum concentration of 2.1 μg/ml at 8 h. The mean urinary excretion during the first 6 h was 75 and 66%, respectively. When amikacin was administered at a dose of 150 mg/m 2 every 6 h, there was evidence of some drug accumulation. A loading dose of 150 mg/m 2 administered intravenously over 30 min followed by 200 mg/m 2 administered as a continuous infusion every 6 h maintained serum concentrations of 8 μg/ml. No major toxicity was observed with any of these drug regimens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference7 articles.

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3. Grove D. A. and W. A. Randall. 1955. Assay methods of antibiotics: a laboratory manual p. 188-196. Medical Encyclopedia Inc. New York.

4. BB-K8, a new semisynthetic aminoglycoside antibiotic;Kawaguchi H.;J. Antibot.,1972

5. Rapid estimation of standard errors of means for small samples;Mantel N.;Amer. Statist.,1951

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