In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections-Reference-Cited by-同舟云学术

In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections

Published:1997-07 Issue:7 Volume:41 Page:1609-1611
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Deguchi T¹,Kawamura T¹,Yasuda M¹,Nakano M¹,Fukuda H¹,Kato H¹,Kato N¹,Okano Y¹,Kawada Y¹

Affiliation:

1. Department of Urology, Gifu University School of Medicine, Gifu-shu, Japan.

Abstract

We report two cases of failure of fluoroquinolone treatment of urinary tract infections with Klebsiella pneumoniae strains harboring quinolone resistance-associated alterations in GyrA and ParC and in vivo selection of posttreatment isolates with enhanced fluoroquinolone resistance. Active efflux leading to decreased accumulation of a drug enhanced fluoroquinolone resistance in one posttreatment isolate, and an additional mutation in parC resulting in an additional amino acid change in ParC was associated with increased resistance in the other.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.41.7.1609

Reference16 articles.

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3. Cross-resistance to nalidixic acid, trimethoprim, and chloramphenicol associated with alterations in outer membrane proteins of Klebsiella, Enterobacter, and Serratia;Gutmann L.;J. Infect. Dis.,1985

4. Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli;Heisig P.;Antimicrob. Agents Chemother.,1996

5. Hirai K. 1989. Quinolone-resistance mechanisms involved in outer membrane p. 187-201. In P. B. Fernandes (ed.) International telesymposium on quinolones. J. R. Prous Science Publishers Barcelona Spain.

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