Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects-Reference-Cited by-同舟云学术

Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects

Published:2019-02-27 Issue:1 Volume:4 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Schlaepfer Erika¹,Fahrny Audrey¹,Gruenbach Maarja¹,Kuster Stefan P.¹,Simon Viviana²,Schreiber Gideon³,Speck Roberto F.¹^ORCID

Affiliation:

1. Department of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland

2. Department of Microbiology, The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

3. Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel

Abstract

Elucidating the functional role of the IFN-α subtypes is of particular importance for the development of efficacious therapies using exogenous IFN-α. Specifically, this will help define whether IFN therapy should be based on the use of pathogen-dependent IFN subtypes or, rather, IFN mutants with optimized IFNAR binding properties.

Funder

Clinical Research Priority Program of the University of Zurich

Theodor und Ida Herzog-Egli Stiftung

HHS | NIH | National Institute of Allergy and Infectious Diseases

Swiss National Science Foundation

Minerva Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00637-18