Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection-Reference-Cited by-同舟云学术

Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection

Published:2022-02-07 Issue:8 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Schuhenn Jonas¹^ORCID,Meister Toni Luise²,Todt Daniel²³,Bracht Thilo⁴⁵,Schork Karin⁴⁶^ORCID,Billaud Jean-Noel⁷^ORCID,Elsner Carina¹^ORCID,Heinen Natalie²^ORCID,Karakoese Zehra¹,Haid Sibylle⁸^ORCID,Kumar Sriram⁹^ORCID,Brunotte Linda⁹¹⁰^ORCID,Eisenacher Martin⁴⁶,Di Yunyun¹¹^ORCID,Lew Jocelyne¹²,Falzarano Darryl¹²^ORCID,Chen Jieliang¹³,Yuan Zhenghong¹³,Pietschmann Thomas⁸¹⁴¹⁵^ORCID,Wiegmann Bettina¹⁶,Uebner Hendrik¹⁷,Taube Christian¹⁷,Le-Trilling Vu Thuy Khanh¹^ORCID,Trilling Mirko¹^ORCID,Krawczyk Adalbert¹¹⁸^ORCID,Ludwig Stephan⁹¹⁰^ORCID,Sitek Barbara⁴⁵,Steinmann Eike²,Dittmer Ulf¹,Lavender Kerry J.¹¹^ORCID,Sutter Kathrin¹^ORCID,Pfaender Stephanie²

Affiliation:

1. Institute for Virology, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany

2. Molecular and Medical Virology, Ruhr-University Bochum, 44801 Bochum, Germany

3. European Virus Bioinformatics Center (EVBC), 07743 Jena, Germany

4. Medical Proteome Center, Ruhr-University Bochum, 44801 Bochum, Germany

5. Department of Anesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Knappschaftskrankenhaus Bochum, 44892 Bochum, Germany

6. Center for Protein Diagnostics, Medical Proteome Analysis, Ruhr-University Bochum, 44801 Bochum, Germany

7. Qiagen Digital Insights, Redwood City, CA 94063

8. Department of Experimental Virology, Twincore, 30625 Hannover, Germany

9. Institute of Virology Muenster, Westfaelische Wilhelms-University, 48149 Muenster, Germany

10. Interdisciplinary Centre for Clinical Research, University of Muenster, 48149 Muenster, Germany

11. Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada

12. Vaccine and Infectious Disease Organization–International Vaccine Centre, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada

13. Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200433, China

14. Cluster of Excellence RESIST, Hannover Medical School, 30625 Hannover, Germany

15. German Center for Infection Research, Partner Site Hannover-Braunschweig, 30625 Hannover, Germany

16. Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany

17. Department of Pulmonary Medicine, Experimental Pneumology, University Medical Center Essen - Ruhrlandklinik, 45239 Essen, Germany

18. Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, 45122 Essen, Germany

Abstract

Significance Type I interferons (IFN-I) exhibit various biological effects during viral infections, and they have been successfully used for clinical treatment of viral diseases. Humans express 12 IFNα subtypes, which strongly differ in their antiviral responses against different viruses. Here we analyzed the antiviral activity of all human IFNα subtypes against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to identify the underlying immune signatures and explore their therapeutic potential. Our data provide a systemic pattern of antiviral host effector responses mediated by high antiviral IFN-I, which could help to identify key cellular effectors targeted in novel therapeutic approaches against SARS-CoV-2 infection.

Funder

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2111600119

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