Effect of HIV Envelope Vaccination on the Subsequent Antibody Response to HIV Infection

Author:

Ditse Zanele12,Mkhize Nonhlanhla N.12,Yin Michael3,Keefer Michael4,Montefiori David C.5,Tomaras Georgia D.5,Churchyard Gavin67,Mayer Kenneth H.8,Karuna Shelly9,Morgan Cecilia9,Bekker Linda-Gail10,Mlisana Koleka1112,Gray Glenda913,Moodie Zoe9,Gilbert Peter914,Moore Penny L.1215ORCID,Williamson Carolyn101215,Morris Lynn1215ORCID

Affiliation:

1. National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS), Johannesburg, South Africa

2. Department of Virology, University of the Witwatersrand, Johannesburg, South Africa

3. Department of Medicine, Columbia University, New York, New York, USA

4. Department of Medicine, University of Rochester, Rochester, New York, USA

5. Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA

6. Aurum Institute, Parktown, South Africa

7. School of Public Health, University of Witwatersrand, Johannesburg, South Africa

8. Fenway Health, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

9. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

10. Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa

11. University of Kwa-Zulu Natal, Durban, South Africa

12. National Health Laboratory Service, Johannesburg, South Africa

13. South African Medical Research Council, Cape Town, South Africa

14. Department of Biostatistics, University of Washington, Seattle, Washington, USA

15. Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

Abstract

There is a wealth of information on HIV-specific vaccine-induced immune responses among HIV-uninfected participants; however, data on immune responses among participants who acquire HIV after vaccination are limited. Here we show that HIV-specific binding antibody responses in individuals with breakthrough HIV infections were not affected by prior vaccination with HIV envelope-containing immunogens. We also found that these vectored vaccines did not prime tier 2 virus-neutralizing antibody responses, which are thought to be required for prevention against HIV acquisition, or accelerate the development of neutralization breadth. Although this study is limited, such studies can provide insights into whether vaccine-elicited antibody responses are boosted by HIV infection to acquire broader neutralizing activity, which may help to identify antigens relevant to the design of more effective vaccines.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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