Evolution and Population Dynamics of Clonal Complex 152 Community-Associated Methicillin-Resistant Staphylococcus aureus

Author:

Baig Sharmin1,Rhod Larsen Anders1,Martins Simões Patrícia2,Laurent Frédéric2,Johannesen Thor Bech1,Lilje Berit1,Tristan Anne2,Schaumburg Frieder3ORCID,Egyir Beverly4,Cirkovic Ivana5,Nimmo Graeme R.6,Spiliopoulou Iris7,Blanc Dominique S.8,Mernelius Sara910,Moen Aina Elisabeth Fossum111213,David Michael Z.14,Andersen Paal Skytt115,Stegger Marc1ORCID

Affiliation:

1. Department of Bacteria, Parasites, and Fungi, Statens Serum Institut, Copenhagen, Denmark

2. Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France

3. Institute of Medical Microbiology, University Hospital Münster, Münster, Germany

4. Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana

5. Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

6. Pathology Queensland Central Laboratory, Griffith University School of Medicine, Queensland Health, Brisbane, Queensland, Australia

7. National Reference Laboratory for Staphylococci, Department of Microbiology, School of Medicine, University of Patras, Patras, Greece

8. Service of Hospital Preventive Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

9. Laboratory Medicine, Jönköping, Region Jönköping County, Sweden

10. Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

11. Department of Clinical Molecular Biology (EpiGen), Division of Medicine, Akershus University Hospital, Lørenskog, Norway

12. Department of Microbiology and Infection Control, Akershus University Hospital, Lørenskog, Norway

13. University of Oslo, Oslo, Norway

14. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

15. Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark

Abstract

Understanding the evolution of CA-MRSA is important in light of the increasing importance of this reservoir in the dissemination of MRSA. Here, we highlight the story of the CA-MRSA CC152 lineage using whole-genome sequencing on an international collection of CC152. We show that the evolution of this lineage is novel and that antibiotic usage may have the potential to select for the phage-encoded Panton-Valentine leukocidin. The diversity of the strains correlated highly to geography, with higher level of resistance observed among the European MRSA isolates. The mobility of the SCC mec element is mandatory for the emergence of novel MRSA lineages, and we show here distinct acquisitions, one of which is linked to the successful clone found throughout Europe today.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference32 articles.

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