A Genome Epidemiological Study of SARS-CoV-2 Introduction into Japan-Reference-Cited by-同舟云学术

A Genome Epidemiological Study of SARS-CoV-2 Introduction into Japan

Published:2020-12-23 Issue:6 Volume:5 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Sekizuka Tsuyoshi¹,Itokawa Kentaro¹,Hashino Masanori¹,Kawano-Sugaya Tetsuro¹,Tanaka Rina¹,Yatsu Koji¹,Ohnishi Asami²,Goto Keiko³,Tsukagoshi Hiroyuki⁴,Ehara Hayato⁵,Sadamasu Kenji⁶,Taira Masakatsu⁷,Shibata Shinichiro⁸,Nomoto Ryohei⁹,Hiroi Satoshi¹⁰,Toho Miho¹¹,Shimada Tomoe¹²,Matsui Tamano¹²,Sunagawa Tomimasa¹²,Kamiya Hajime¹²,Yahata Yuichiro¹²,Yamagishi Takuya¹²,Suzuki Motoi¹²,Wakita Takaji¹³,Kuroda Makoto¹^ORCID

Affiliation:

1. Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan

2. Sapporo City Institute of Public Health, Sapporo, Japan

3. Ibaraki Prefectural Institute of Public Health, Ibaraki, Japan

4. Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma, Japan

5. Saitama Prefectural Institute of Public Health, Saitama, Japan

6. Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan

7. Division of Virology and Medical Zoology, Chiba Prefectural Institute of Public Health, Chiba, Japan

8. Microbiology Department, Nagoya City Public Health Research Institute, Aichi, Japan

9. Department of Infectious Diseases, Kobe Institute of Health, Kobe, Hyogo, Japan

10. Division of Microbiology, Osaka Institute of Public Health, Osaka, Japan

11. Fukui Prefectural Institute of Public Health and Environmental Science, Fukui, Japan

12. Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan

13. National Institute of Infectious Diseases, Tokyo, Japan

Abstract

This study aimed to evaluate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome sequences from COVID-19 cases and to characterize their genealogical networks to demonstrate possible routes of spread in Japan. We found that there were at least two distinct SARS-CoV-2 introductions into Japan, initially from China and subsequently from other countries, including Europe. Our findings can help understand how SARS-CoV-2 entered Japan and contribute to increased knowledge of SARS-CoV-2 in Asia and its association with implemented stay-at-home/shelter-in-place/self-restraint/lockdown measures. This study suggested that it is necessary to formulate a more efficient containment strategy using real-time genome surveillance to support epidemiological field investigations in order to highlight potential infection linkages and mitigate the next wave of COVID-19 in Japan.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00786-20

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